229 Pancreatic genotype–phenotype co-variations in cystic fibrosis

Pancreatic cystosis in cystic fibrosis.

To cite: Burt H, Andronikou S, LangtonHewer S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015214288 DESCRIPTION A 17-year-old boy was diagnosed with cystic fibrosis at age 6 years. Genetic analysis revealed homozygous ΔF508 mutations. His first abdominal ultrasound was performed in March 2012 as part of the annual cystic fibrosis review. This demonstrated an...

prevalence of pancreatic insufficiency & ftt in cystic fibrosis

cystic fibrosis (cf) is an inherited disease that affects multiple organ systems. it is the most common cause of severe progressive lung disease and exocrine panceratic insufficiency. in our investigation 67 patients had cf. of these, 79% had panceratic insufficiency and 92% had lung disease under 2 years age. also 67% of patients were < 2 percentile and 28% between 3-10 percentile weight for a...

Pancreatic enzyme supplementation in cystic fibrosis.

Pancreatic enzyme supplements in cystic fibrosis.

Approximately 95% of patients in Northern Europe are pancreatic insufficient due to an inadequacy of their own pancreatic enzyme secretions (Littlewood et al, 2006). These patients need to take pancreatic enzyme replacement therapy (PERT) in order to prevent the symptoms of fat malabsorption. These symptoms include frequent pale, oily and offensive stools, abdominal pain, poor growth and defici...

Serum pancreatic lipase activity in cystic fibrosis.

Patients with cystic fibrosis have been found to have abnormal serum concentrations of immunoreactive trypsin and abnormal activities of pancreatic isoamylase. A study was undertaken to discover whether activity of pancreatic lipase is also altered in cystic fibrosis. Serum from 23 patients with cystic fibrosis was assayed for immunoreactive trypsin and pancreatic lipase. Median serum pancreati...